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High uric acid crystal deposition would lead to both increased hyaluronan (HA) expression and fragmentation and low molecular weight HA fragments bind to toll like receptors (TLR2) and down regulate TSH releasing hormone leading to chronically low or low normal TSH levels with simultaneous low or very low normal T3/T4. I think this would be the cause of Gout-associated hypothyroidism and why replacement therapy might be in order for some.
THEN about 2 months ago I developed redness at the corners of my lips and a red lesion on the bottom that would not heal
I developed very similar lesions as a long time vegetarian who had also been prescribed very high dose PPIs (proton pump inhibitors) for GERD. The lesions disappeared magically with high dose methycobalamin (active form of Vit B12) and recur when I do not take enough. Inflammation uses up a ton of B12 and vegans are particularly at risk. You might want to try some sublingual methylcobalamin dots – I have to take 15mg sublingually (under the tongue) when my inflammation is bad. (I also got off the PPI’s, they were making things worse over time and have managed it with diet and weight loss).
just one possibility….
